The author of the study concluded that this case of ITP may have been vaccine related. If you have a single nucleotide polymorphism in one of those RNases called RNase-L, you are more likely to get aggressive breast cancers, prostate cancers and other cancers from an XMRV infection (So why inject mRNA of syncytin, a gamma retrovirus envelope? To date, VAERS has received no reports of CVST with thrombocytopenia among persons who received either of the two mRNA-based COVID-19 vaccines. I haven’t seen this done yet. There are dozens of causes of thrombocytopenia. I am careful not to say, "caused by vaccination," because coincidence, pre-disposition, and other contributing factors are unknown and likely. There have been reports of haemorrhage, blood clots and thrombocytopenia following administration of CoViD-19 vaccines [1]. Distinguishing vaccine‐induced ITP from coincidental ITP presenting soon after vaccination is impossible at this time. https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-... https://www.nytimes.com/2021/01/12/health/covid-vaccine-death.html. Vaccines have been suspected of playing a role in inducing autoimmune disease (AID) for a long time. Even most of those that were more severe recovered with treatment (dexamethasone, platelet transfusion, and IVIG). The patient was hospitalized and tested for other infections and autoimmune conditions to search for an alternate diagnosis. Platelets are membrane bound cell-like entities that circulate in the blood stream, whose main function is to assist with blood clotting. The difference between petechiae and purpura in thrombocytopenia versus regular bruising, is that these rashes occur spontaneously. A key ingredient in Johnson & Johnson’s Covid-19 vaccine could explain the possible link between the shots and the extremely rare blood clots reported in six patients in the U.S. Bruising for no apparent reason and bleeding are common symptoms of … The prevalence (how many adults have ITP at any time) is 9.5 cases per 100,000. Page 3/5 . Keywords: covid 19, immune thrombocytopenia purpura, drug-induced itp, mrna-based vaccine, drug rash. According to the Vaccine Adverse Event Reporting System (VAERS), there were 309 cases of thrombocytopenia (low platelets) reported as of Mar 26. This molecular mimicry had been proposed in the past as a classic mechanism responsible for the vaccine associated ITP. As of today, there are at least twenty-seven similar cases submitted to the Vaccine Adverse Event Reporting System (VAERS). So, all together, thrombo-cyto-penia means a deficiency of the “cells” that help blood to clot. more than 1 in 100 vaccinated persons) , respectively. The mRNA … AAPS … On post-vaccination day six, the patient’s rash and gum bleeding decreased, his platelets count improved to 28,000 and he was able to leave the hospital. For the second time in under a… This makes sense that vaccine recipients have a lower incidence of ITP than the general population, as many of the first recipients are young and healthy healthcare workers. Thrombocytopenic means that the condition is defined by a low platelet count. Malayala SV , Mohan G , Vasireddy D , Atluri P Cureus , 13(3):e14099, 25 Mar 2021 It’s certainly possible that there are more cases yet to be identified or reported, but it’s also possible that many will be attributed to other causes. They both are what are called mRNA vaccines, which function very differently than the types of vaccines used in the past. Reports from various European countries on the AZ/Oxford side effects have not always lined up, so we don't know yet how the J&J ones fit into the picture. Caption: Subtle example of petechiae on the inside of the lower lip, Image attribution: Mdscottis, CC BY-SA 3.0 https://creativecommons.org/licenses/by-sa/3.0, via Wikimedia Commons. There have been over 150 reports of post-CoViD19 vaccination thrombocytopenia recorded in the pharmacovigilance databases at VAERS [5] and MHRA [6], and at least one confirmed death in USA which is still under investigation [7]. It says it right there on the package insert. Good question. Petechiae and purpura are usually caused by the same thing — bleeding within the skin. There have been at least 43 cases of immune thrombocytopenia recorded in VAERS database with Pfizer and Moderna CoViD-19 vaccines [5], and there is at least one death reported with immune thrombocytopenia after Pfizer … Platelets are anucleate cells that continue to defy conventional logic; they are involved in mRNA translation and known to synthesise proteins for over fifty years [4]. So many doses have been administered that these unusual … It’s also worth considering that 27 cases out of 45 million is a rate of 0.06 out of every 100,000 people. A Few Covid Vaccine Recipients Developed a Rare Blood Disorder: A link to the vaccines is not certain, and investigations are underway in some reported cases. mRNA vaccines are similarly new, but they have so far racked up a good safety record. It has been proposed that the antibodies produced by the body to clear the virus have a potential cross reactivity with surface antigens on platelets or megakaryocytes. The most compelling case linking ITP to Covid-19 mRNA vaccination is the case mentioned at the beginning of this piece. In authors opinion, it is highly likely that RNA viruses can directly infect platelets and mRNA translation within platelets is a possible explanation for the autoimmune response against platelets instead of previously proposed molecular mimicry theory. ", The prefix “thrombo-“ means “relating to the clotting of blood.”. No large trials of any mRNA vaccine have been completed yet. The prevalence (how many adults have ITP at any time) is 9.5 cases per 100,000. ).” This information aims to help people in the following groups make an informed decision about receiving a COVID-19 vaccine. How to keep ahead of viral variants and have boosters ready. Meanwhile, the Pfizer/BioNTech vaccine had 95% efficacy, and the Moderna vaccine had 94% efficacy at preventing symptomatic COVID-19, meaning any … It is also noted that thrombocytopenia may be a minor consideration due to the need for an intramuscular injection – they state that a platelet count of >20×10 9 /L would be preferable. mRNA vaccines are similarly new, but they have so far racked up a good safety record. Because these rashes are caused by bleeding within the skin, they are distinguishable from other rashes by their inability to blanch. mRNA vaccines used for therapeutic purposes such as those used in cancer or HIV treatment are also outside the scope of this report. It, however, requires substantial evidence to confirm this hypothesis. If you have a single nucleotide polymorphism in one of those RNases called RNase-L, you are more likely to get aggressive breast cancers, prostate cancers and other cancers from an XMRV infection (So why inject mRNA of syncytin, a gamma retrovirus envelope? ‘There is a race to get the public vaccinated, so we are willing to take more risk.' Besides SARS-CoV-2, various other pathogens are known to induce ITP, notably Helicobacter pylori, H3N2 influenza virus and the Dengue virus. None were found, save a single abnormal antibody titer that is usually associated with Sjogren’s disease (an autoimmune disease). https://creativecommons.org/licenses/by-sa/3.0, https://creativecommons.org/licenses/by/4.0. Under normal circumstances, there are approximately 150,000 to 450,000 platelets in one microliter of blood. We know mRNA vaccine technology is … https://www.wusa9.com/article/news/health/coronavirus/vaccine/rockville-covid-vaccine-serious-side-effects-rare-blood-disorder-itp-thrombocytopenia/65-37336643-c641-49e0-8f52-1808513f42d9. Short-term side effects (i.e., those that happen in the days after a vaccine has been given) are readily apparent because of clinical trial reports and personal experiences, but people also wonder about possible long-term effects of these vaccines. It is estimated that approximately 1:40 000 children develop secondary ITP after receiving measles‐mumps‐rubella (MMR) vaccine. COVID-19 vaccines may be administered to most people with underlying medical conditions once vaccine is available to them. The PRAC assessment of the ITP cases reported to EudraVigilance (see section 3) for Comirnaty from vaccination campaigns . Purpuric Rash and Thrombocytopenia After the mRNA-1273 (Moderna) COVID-19 Vaccine. 8-10 On the other hand, the only case–controlled study of adult recipients of all vaccines … The mRNA vaccines contain a genetic code that trains the immune system to recognize the spike protein on the surface of the virus to generate an immune response and fight it. It says it right there on the package insert. Caption: Less subtle example of purpura on the ankle and leg, with small petechiae on the calf, shin, and just below the knee. According to the CDC, roughly 45 million people have been vaccinated as of February 10, 2021 at 0900 ET. Thrombocytopenia is simply the medical term for "low platelets. On post-vaccination day eleven, repeat labs demonstrated a normal platelet count of 173,000 and he tested positive for anti-iib/iiia and ia/iia antibodies which is suggestive of ITP. Allergic reactions and anaphylaxis. This is less than one-tenth of the estimated annual incidence. This is also a likely explanation for the thrombocytopaenia prevalence in patients infected with Dengue virus. It included 11 patients in Germany and Austria who presented with unusual thromboses and moderate to severe thrombocytopenia, five to 16 days after receiving the AstraZeneca vaccine… https://www.ema.europa.eu/en/news/covid-19-vaccine-astrazeneca-prac-inve... Women’s, children’s & adolescents’ health. CoViD Vaccines and thrombotic events: Possibility of mRNA translation and spike protein synthesis by platelets. Also, consider that thrombocytopenia and even severe ITP has been reported in natural Covid-19 infection as well. Another vaccine recipient, Sarah C., 48, a teacher in Arlington, Tex., received the Moderna vaccine on Jan. 3. Platelets then become deficient, causing thrombocytopenia. Vaccine manufacturers and regulators are examining rare instances of immune thrombocytopenia that have occurred in people who've received one of the two authorized mRNA COVID-19 vaccines in the United States, the New York Times reports.. Out of 31 million people who've received at least one vaccine dose, nearly 40 cases of thrombocytopenia had been reported to … According to rarediseases.org: The incidence (how many people are diagnosed each year) of ITP among adults in the USA is estimated to be 3.3 per 100,000 adults/year. These reports following the J&J COVID-19 vaccine are similar to reports of thrombotic events with thrombocytopenia after receipt of the AstraZeneca COVID-19 vaccine in Europe. The COVID-19 pandemic led to 117 million infections and 2.6 million deaths worldwide by March 2021 . Could mRNA COVID-19 vaccines be dangerous in the long-term? So, mRNA vaccines are just a type of vaccine where we package the RNA instructions for some of the SARS-CoV-2 proteins (the virus that causes COVID-19). A microliter is 0.0002 teaspoons. user md chat icon. Three COVID-19 vaccines – two mRNA vaccines from Pfizer-BioNTech and Moderna and one recombinant, replication-incompetent human adenovirus serotype 26 (Ad26) vector vaccine from Janssen Biotech, have received emergency use authorization (EUA) in the United States from the Food and Drug Administration and are currently being administered to people in the US. He had no history of these problems. It says it right there on the package insert. ).” Many patients with Dengue fever recover from thrombocytopaenia over time suggesting a highly selective immune response against infected platelets or megakaryocytes. The term immune means that the condition is mediated by an abnormality of the immune system. The first, his AST and ALT (liver enzymes), were mildly elevated; the second, his platelets were 2000 per microliter compared to a value of 145,000 per microliter measured just two months prior. In the picture below is a red blood cell (red), white blood cell (blue), and a platelet (yellow). To date, no cases of GBS have been reported following vaccination in participants in the mRNA COVID-19 vaccine clinical trials. It’s the only case documented in the medical literature thus far. The only evidence on safety of mRNA vaccines comes from small phase I and phase II trials of SARS-CoV-2 vaccines, with follow-up typically less than two months. However, apart from certain specific vaccine strains and complications (such as the swine flu vaccine and Guillain-Barré syndrome in 1976, thrombocytopenia and the Measles-Mumps-Rubella vaccine), this role has not been established. Than you would expect regardless of vaccination this time have questions about getting COVID-19 vaccine clinical can! 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