Exon “choice” is tightly regulated, allowing generation of different proteins from same gene in different cells. Alternative splicing.ppt - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. For some genes, exons are “skipped” during splicing to generate alternative RNA products. RNA Splicing Definition. (RNA is called hnRNA -Heteronuclear RNA before splicing occurs)• Splicing is: -The mechanism by which introns are removed.• ÐSplice donor: 5Õ end of intron: exon-G-U ÐSplice Acceptor: 3Õ end of intron: A-G-exon Apr 13, 2021 - RNA Splicing - PPT (Powerpoint Presentation), Semester, Engineering Notes | EduRev is made by best teachers of . 7. Alternative RNA splicing • Two forms of IgM are found: membrane-bound IgM (monomer) and secreted IgM pentamer) • The membrane and secreted forms of an Ig molecule are coded by additional short exons at the 3 / end of the C gene: a. the transmembrane region plus the cytoplasmic tail b. The spliced RNA is released and the lariat debranches. factors and/or gene-specific splicing regulators during. `Trans-splicing `RNA editing; change the mRNA after it is made ⌧Insertions or deletions ⌧Base deamination. This document is highly rated by students and has been viewed 487 times. RNA splicing is a form of RNA processing in which a newly made precursor messenger RNA (mRNA) is transformed into a mature RNA by removing the non-coding sequences termed introns.. Why is splicing so accurate? Different growth factor (FGF) receptors are synthesized due to selective use of exons 5, 6, or 7 into the mRNA. The pre-rRNA of Tetrahymena thermophila was found to undergo ‘self-splicing’ in vitro without the need for a protein catalyst and it was one of the first RNA molecules to be discovered to have enzymatic activity. RNA SPLICING• RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule. RNA splicing is a fundamental feature of the processing of RNA in many organisms. Mechanism of Splicing ¥There is an intranuclear protein/RNA complex called the splicosome that ensures proper splicing. 6. Proteins – SR proteins and hnRNPs 2. cis elements in introns and exons – splicing enhancers and silencers Differences in the activities and/or amounts of general splicing. Alternative Poly (A) sites aThyroid `First poly(A) site `Exon 4 retained `Produces ⌧Calcitonin aBrain `Second poly(A) site predominates `Exon 4 spliced out Splicing of regulated exons is modulated: 1. development or in differnt tissues can cause alternative splicing- The resulting RNA-protein cross-exon recognition complex spans an exon and activates the correct splice sites for RNA splicing and this exon is retained in the final spliced mRNA. Alternative Poly (A) sites and alternative Splicing. Introns are small-large; Exons are about 150bp long Rearrangements that occur during splicing U1 replaced by U6 BBP (branch binding protein) and U2 U5 complex branch forming enzymes in U6 and U2 Allows for check and recheck at each splice site. The process of RNA splicing involves the removal of non-coding sequences or introns and joining of the coding sequences or exons. ¥Three types of short sequences dictate the precise cutting of the intron/exon boundaries - called splice junctions. 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